Insulin on the Brain: Determining How Insulin Signalling in the Brain Coordinates Glucose Homeostasis
Grant number: 1160043 | Funding period: 2019 - 2022
Completed
Abstract
Type 2 diabetes (T2D) results in 3.7 million deaths each year. T2D is characterised by impaired blood sugar control (glucose homeostasis) due to defective insulin signalling. Insulin is secreted after a meal by the pancreas to instruct the muscle/fat to uptake glucose from the blood. Insulin also signals to the brain but the significance of this remains unclear. We aim to determine where & how insulin is integrated into the brain and determine its contribution to glucose homeostasis and T2D.